Clinical research site operators face a constant stream of compliance obligations, legal requirements, operational challenges, and business risks that can create a form of "alarm fatigue." While every obligation deserves attention, not every mistake carries the same consequences. Some errors create minor disruptions, while others can result in significant financial exposure, regulatory scrutiny, reputational harm, or even threaten the viability of a research program. In this session, experienced leaders in law, clinical operations, and risk management will cut through the noise and share their short list of high-impact mistakes every site should understand, helping attendees focus their time and resources on the risks most likely to leave a lasting mark.