Choosing whether to conduct Coverage Analysis in-house, outsource to a vendor, or adopt a hybrid model is a critical decision for clinical research programs. This session will explore the key financial, operational, and staffing considerations that influence this choice, including program size, trial portfolio, and system capabilities. Attendees will gain insight into the challenges of hiring and retaining skilled staff, maintaining quality control, and managing workload fluctuations. We will also discuss best practices for ensuring efficiency and compliance across different models. By the end of the session, participants will be equipped to assess and implement the most effective approach for their institution’s needs.