The clinical research industry continues to undergo significant transformation, with the consolidation of research sites and healthcare systems reshaping the landscape. This session will explore the evolving dynamics of mergers and acquisitions, with insights into recent trends and expectations for 2025 and beyond. Presenters will share practical guidance for clinical research sites and other pharma service organizations preparing for potential acquisition. Additionally, attendees will hear lessons learned from the merger of two of Michigan’s largest healthcare systems. This case study will highlight the creation of a unified research institute, strategies for harmonizing research operations, aligning policies, and managing cross-state collaborations