Brian Barnes is a clinical operations leader with over 20 years of experience driving innovation in global clinical research, with a focus on quality management, operational oversight, and digital transformation. At BioNTech, he leads enterprise-level risk management strategy and has been instrumental in introducing AI technologies into clinical trial operations to improve efficiency, enhance oversight, and strengthen data integrity.

His career spans leadership roles at Medidata and PPD, where he helped design and deploy AI-enabled tools supporting centralized monitoring, remote oversight, and risk-based quality frameworks. Brian is a frequent industry speaker and contributor to initiatives shaping the future of tech-enabled clinical trials, including collaborations with ACRO, TransCelerate, and AVOCA.

He currently serves on several expert working groups focused on advancing AI adoption, risk-based thinking, and quality-by-design approaches across the clinical research ecosystem.