Join us for a compelling dive into the background and evolution of clinical research ethics and regulations. Discover how early medical experiments paved the way for establishing principles and policies that set crucial standards for consent and human rights. Uncover the dark legacies of early 20th-century research projects and their role in shaping today’s governing structures and sanctioned requirements. Explore the essentials of Good Clinical Practice (GCP), the pivotal role of Institutional Review Boards (IRBs), and the vital phases of clinical trials. Learn about key regulatory bodies like the FDA, EMA, and ICH, and tackle today’s ethical challenges, from balancing risks and benefits to ensuring trial diversity. Join us on this captivating journey through the principles that protect and guide clinical research.