This session shares the story of a large-scale research operations transformation that achieved measurable success within one year by leveraging Coverage Analysis as a core operational driver. Presenters will discuss how changing the coverage analysis process has created new frameworks that significantly reduce study startup timelines, strengthen regulatory alignment, and advance industry partnerships in new ways. The session highlights how compliance infrastructure can accelerate research activation when embedded early and consistently. Attendees will gain practical strategies for building efficient, audit-ready research operations that sustain performance across one of the nation’s largest integrated health system and payer-provider models.